Endocrine Abstracts

Introduction: The presence of glandular breast tissue in males around puberty, pubertal gynaecomastia, is a very common (40–60%) condition although the aetiology behind is poorly understood. It is generally accepted that pubertal gynaecomastia is caused by an excess of estrogens and/or a deficit of androgens. However, other hormones such as prolactin, GH and IGF1 may also affect ductal growth of the breast.Design: A cross-sectional study of 518 heal...

Introduction: The UGT2B17 gene encodes a glucuronidase which is important for the urinary excretion of testosterone. Recent studies have shown that a common deletion polymorphism in UGT2B17 is strongly associated with significant lower levels of excreted urinary testosterone in men. The objective of this study was to investigate the association of the UGT2B17 gene polymorphism and the dosages of testosterone substitution in male patients with frank hypogonadism.<p class="a...

Objective: IGF1 has almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycaemic response. Studies showed that low and high IGF1 levels are related to impaired glucose tolerance and to a higher risk of type two diabetes. The aim of the present study was to evaluate the association between IGF1 level and insulin resistance in a Danish general population.Research Design and Methods: From the cross-sectional Health2006 stud...

Objective: Recent publications showing unexpectedly early breast development in American girls created debate worldwide. However, secular trend analyses are often limited by poor data comparability among studies done by different researchers in different time periods and populations. Here, we present new European data, systematically collected from the same region and by one research group at the beginning and end of the recent 15 year period.Methods: Tw...

Background: Previous studies have demonstrated a high overall prevalence of testicular adrenal rest tumors (TART) in adults with congenital adrenal hyperplasia (CAH), whereas little is known about the prevalence in children. The aim of this study was to determine the presence of TART according to age and genotype.Design: Retrospective study, tertiary University centre.Patients and methods: In 47 male patients (age 2.6–40.3 yea...

Objective: To estimate the occurrence of hypopituitarism 12 months following traumatic brain injury (TBI), describe the time course, evaluate the predictive value of early hormonal changes and trauma related parameters, as well as out-come.Methods Forty-six patients with TBI (mild (GCS:13–15) n=22; moderate (GCS:9–13) n=9; severe (GCS<9) n=15) were included. Patients were tested early post-injury (baseline hormone level...

Context: Steroid hormone-producing tumors account for 0.1% of all primary ovarian tumors. According to the cellular origin they are classified into stromal luteomas, Leydig cell tumors and steroid tumors not otherwise specified. Symptoms and phenotype depend on the specific hormones and concentrations released from the tumor. In this report, we present a postmenopausal woman with virilization during two pregnancies and in menopause caused by an androgen producing ovarian tumor...

Background and Purpose: Infertility affects 15% of couples globally, and only few treatment options are available. Gonadotropins are classic and potent regulators of ovarian and female reproductive function, but novel endocrine crosstalk appears to exist between gonads and the skeleton that may influence female fertility. One of the new players include the RANKL signalling system, which consists of the receptor activator of nuclear factor κβ ligand (RANKL), the recep...

Background: Numerous studies have suggested that optimal vitamin D status increases treatment success of women undergoing assisted reproductive treatments. However, conflicting data exist, and the relationship remains controversial, prompting the need for more comprehensive studies investigating all the metabolites of vitamin D in women undergoing IVF/ICSI treatment. Objective: To investigate the relationship between follicular fluid levels of the three ...

Testosterone (T) is excreted in urine as water soluble glucuronidated and sulphatated conjugates. The ability to glucuronidate T and other steroids depends on a number of different glucuronidases (UGT) of which UGT2B17 is essential. The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys.Study design: A clinical study of 116 healthy boys aged 8 to 19 years. UGT2B17</i...